Microbiome
In this project, we address methodological issues in the context of high-dimensional data from microbiome studies. A particular focus is on the analysis of complex data structures such as clustered data from longitudinal studies or meta-analyses in combination with pooled analyses of individual patient-level data.
Hagenfeld D, Kleine Bardenhorst S, Matern J, et al. Long-term changes in the subgingival microbiota in patients with stage III–IV periodontitis treated by mechanical therapy and adjunctive systemic antibiotics: A secondary analysis of a randomized controlled trial. Journal of Clinical Periodontology. n/a(n/a). doi:10.1111/jcpe.13824
Kleine Bardenhorst S, Cereda E, Severgnini M, et al. Gut microbiota dysbiosis in Parkinson disease: A systematic review and pooled analysis. European Journal of Neurology. 2023;n/a(n/a). doi:10.1111/ene.15671
Kleine Bardenhorst S, Vital M, Karch A, Rübsamen N. Richness estimation in microbiome data obtained from denoising pipelines. Computational and Structural Biotechnology Journal. 2022;20: 508–520. doi: 10.1016/j.csbj.2021.12.036
Kleine Bardenhorst S, Berger T, Klawonn F, Vital M, Karch A, Rübsamen N. Data analysis strategies for microbiome studies in human populations - a systematic review of current practice. mSystems. 2021;6: e01154-20. doi: 10.1128/mSystems.01154-20
Rath S, Rox K, Kleine Bardenhorst S, Schminke U, Dörr M, Mayerle J, Frost F, Lerch MM, Karch A, Brönstrup M, Pieper DH, Vital M. Higher Trimethylamine-N-Oxide Plasma Levels with Increasing Age Are Mediated by Diet and Trimethylamine-Forming Bacteria. mSystems. 2021;6:e00945-21. doi: 10.1128/mSystems.00945-21
Vital M, Karch A, Pieper DH. Colonic butyrate-producing communities in humans: an overview using Omics data. mSystems. 2017;2(6). pii: e00130-17. doi: 10.1128/mSystems.00130-17.
Rath S, Rud T, Karch A, Pieper DH, Vital M. Pathogenic functions of host microbiota. Microbiome. 2018;6(1):174. doi: 10.1186/s40168-018-0542-0.
Caputo M, Zoch-Lesniak B, Karch A, Vital M, Meyer F, Klawonn F, Baillot A, Pieper DH, Mikolajczyk RT. Bacterial community structure and effects of picornavirus infection on the anterior nares microbiome in early childhood. BMC Microbiol. 2019;19(1):1. doi: 10.1186/s12866-018-1372-8.
Project details
Responsible persons
Project period
July 2021 - July 2023
Cooperation partners
Medizinische Hochschule Hannover
Helmholtz-Zentrum für Infektionsforschung Braunschweig
Funding
Innovative Medical Research (IMF) of the University of Münster (I-RÜ122010)
Hagenfeld D, Kleine Bardenhorst S, Matern J, et al. Long-term changes in the subgingival microbiota in patients with stage III–IV periodontitis treated by mechanical therapy and adjunctive systemic antibiotics: A secondary analysis of a randomized controlled trial. Journal of Clinical Periodontology. n/a(n/a). doi:10.1111/jcpe.13824
Kleine Bardenhorst S, Cereda E, Severgnini M, et al. Gut microbiota dysbiosis in Parkinson disease: A systematic review and pooled analysis. European Journal of Neurology. 2023;n/a(n/a). doi:10.1111/ene.15671
Kleine Bardenhorst S, Vital M, Karch A, Rübsamen N. Richness estimation in microbiome data obtained from denoising pipelines. Computational and Structural Biotechnology Journal. 2022;20: 508–520. doi: 10.1016/j.csbj.2021.12.036
Kleine Bardenhorst S, Berger T, Klawonn F, Vital M, Karch A, Rübsamen N. Data analysis strategies for microbiome studies in human populations - a systematic review of current practice. mSystems. 2021;6: e01154-20. doi: 10.1128/mSystems.01154-20
Rath S, Rox K, Kleine Bardenhorst S, Schminke U, Dörr M, Mayerle J, Frost F, Lerch MM, Karch A, Brönstrup M, Pieper DH, Vital M. Higher Trimethylamine-N-Oxide Plasma Levels with Increasing Age Are Mediated by Diet and Trimethylamine-Forming Bacteria. mSystems. 2021;6:e00945-21. doi: 10.1128/mSystems.00945-21
Vital M, Karch A, Pieper DH. Colonic butyrate-producing communities in humans: an overview using Omics data. mSystems. 2017;2(6). pii: e00130-17. doi: 10.1128/mSystems.00130-17.
Rath S, Rud T, Karch A, Pieper DH, Vital M. Pathogenic functions of host microbiota. Microbiome. 2018;6(1):174. doi: 10.1186/s40168-018-0542-0.
Caputo M, Zoch-Lesniak B, Karch A, Vital M, Meyer F, Klawonn F, Baillot A, Pieper DH, Mikolajczyk RT. Bacterial community structure and effects of picornavirus infection on the anterior nares microbiome in early childhood. BMC Microbiol. 2019;19(1):1. doi: 10.1186/s12866-018-1372-8.