VBD-MODE aims to enhance modelling and prediction of vector-borne disease emergence and outbreak patterns in Germany and estimate current and future disease risk and burden across multiple pathogens with environment- and climate-sensitivity, in order to inform prevention and preparedness needs, and provide recommendations for cost-effective vaccination and surveillance strategies, and thereby strengthen public health and healthcare resilience in Germany. VBD-MODE consists of an interdisciplinary network that will; (i) develop and deploy state-of-the-art de-novo models in eco-epidemiology to investigate and validate short-term forecasts of climate-sensitive emerging disease threats, such as West Nile fever, tick-borne diseases, and Aedes-borne diseases, including dengue, over time and space in Germany; (ii) assess the scenario-based epidemiological threats posed by these diseases under near-current and future climate and land use changes across Germany; and  (iii) develop intervention models to explore the health and economic impact of different (non-)pharmaceutical interventions and surveillance strategies